Automated Modular Synthesis of Aptamer–Drug Conjugates for Targeted Drug Delivery

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Automated Modular Synthesis of Aptamer–Drug Conjugates for Targeted Drug Delivery

Aptamer-drug conjugates (ApDCs) are promising targeted drug delivery systems for reducing toxicity while increasing the efficacy of chemotherapy. However, current ApDC technologies suffer from problems caused by the complicated preparation and low controllability of drug-aptamer conjugation. To solve such problems, we have designed and synthesized a therapeutic module for solid phase synthesis,...

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ژورنال

عنوان ژورنال: Journal of the American Chemical Society

سال: 2014

ISSN: 0002-7863,1520-5126

DOI: 10.1021/ja4117395